Guidance for patients taking GLP-1 treatments during Ramadan

By Dr. Winiger, Medical Director at Dr.Online


As Ramadan approaches, many patients taking GLP-1 receptor agonist therapy with medications such as Mounjaro (tirzepatide) and Wegovy (semaglutide) may have questions about managing their treatment during fasting hours. These medications offer our patients at Dr.Online a great resource to aid weight loss alongside lifestyle changes. Fasting during Ramadan requires thoughtful adjustments to ensure blood sugar stability and overall health.


Understanding Mounjaro and Wegovy

Mounjaro and Wegovy are long-acting GLP-1 receptor agonists administered as once-weekly injections. They improve blood sugar control, reduce appetite, and promote weight loss, making them ideal for individuals living with obesity.
Given their once-weekly dosing schedules, they are generally more convenient during Ramadan, as they don’t require daily adjustments. However, the unique dietary changes during fasting necessitate some key considerations.

Key Recommendations for Mounjaro and Wegovy Users

1. Timing of Administration

  • Both Mounjaro and Wegovy can continue to be administered on the same day of the week as before Ramadan.
  • Consider choosing a time after Iftar (the evening meal) for injections, as this aligns with the body’s ability to process nutrients following a meal and will ensure maximal effect/side effects are during the night when asleep.

2. Dosage Adjustments

  • Typically, no dose adjustments are required for Mounjaro or Wegovy during Ramadan, however, we wouldn’t suggest increasing your monthly dose before undertaking Ramadan.
  • However, if you experience side effects such as nausea or reduced appetite that interfere with meal consumption during Suhur (pre-dawn meal) or Iftar, contact us to discuss potential modifications.

3. Monitoring for Side Effects

  • Common Side Effects: These medications can cause nausea, bloating, or changes in appetite, which might be amplified by fasting.
  • Action Steps: Stay hydrated during non-fasting hours and consume easily digestible, balanced meals. See the link to our resources for more information.

4. Preventing Hypoglycemia (low blood sugars)

  • Although Mounjaro and Wegovy have a low risk of hypoglycemia, those also on insulin or sulfonylureas (eg Gliclazide) may be at greater risk.
  • Consider regularly monitoring your blood glucose, especially during the first few days of Ramadan, to identify trends and adjust your fasting routine.

5. Dietary Considerations

  • Suhur (Pre-Dawn Meal): Opt for complex carbohydrates, lean proteins, and healthy fats to provide sustained energy throughout the fasting day. Avoid salty foods to prevent excessive thirst.
  • Iftar (Evening Meal): Break your fast with a small portion of dates and water, followed by a balanced meal with plenty of vegetables, proteins, and fiber-rich foods.

6. Hydration

  • Drink plenty of water between Iftar and Suhur to stay hydrated and support your metabolic health. Avoid sugary beverages, which can cause postprandial hyperglycemia (spiking high sugars after food).

When to Break Your Fast

While fasting is a religious obligation, Islam allows exceptions for those who are ill or whose health might be compromised.

  • Break your fast immediately if you experience symptoms of hypoglycemia, such as dizziness, sweating, confusion, or shakiness. Treat with a quick source of sugar, such as juice or glucose tablets, and follow up with a balanced snack.
  • Obesity is classified as a disease, so there is leeway if you think it’ll negatively impact your health. It would be worth talking to your Imam or GP to discuss the options if you’re unsure.

Consultation and Personalized Advice

Before Ramadan begins, schedule a consultation with your healthcare provider to review your treatment plan. This is especially important if you’re new to Mounjaro or Wegovy or have recently adjusted your dose.

Conclusion

Fasting during Ramadan while taking Mounjaro or Wegovy is possible with proper planning and monitoring. Stick to your prescribed treatment, maintain a balanced diet, and stay hydrated during non-fasting hours. Most importantly, listen to your body and consult your healthcare provider if you have any concerns.

Wishing you a healthy, safe, and blessed Ramadan.

Dr. Winiger, Medical Director at Dr.Online

References – https://pmc.ncbi.nlm.nih.gov/articles/PMC10761230/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9672258/

 

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